/* ─── Reset & Base ─── */
*, *::before, *::after {
  margin: 0;
  padding: 0;
  box-sizing: border-box;
}

:root {
  --blue-50: #f0f5ff;
  --blue-100: #e0ecff;
  --blue-200: #bdd4fe;
  --blue-500: #3b72d9;
  --blue-600: #2c5fbf;
  --blue-700: #1e4a9e;
  --blue-800: #163a7a;

  --slate-50: #f8f9fb;
  --slate-100: #f1f3f6;
  --slate-200: #e2e6ec;
  --slate-300: #cdd3dc;
  --slate-400: #9aa3b3;
  --slate-500: #6b7689;
  --slate-600: #4e5768;
  --slate-700: #3a4254;
  --slate-800: #272e3b;
  --slate-900: #1a1f2b;

  --red-50: #fef2f2;
  --red-100: #fee2e2;
  --red-500: #dc4a4a;
  --red-600: #c03030;
  --red-700: #a22020;

  --amber-50: #fffbeb;
  --amber-100: #fef3c7;
  --amber-500: #d19a08;
  --amber-600: #b48308;

  --green-50: #f0fdf4;
  --green-100: #dcfce7;
  --green-500: #22a352;
  --green-600: #16843e;

  --surface: #fcfcfd;
  --text-primary: var(--slate-900);
  --text-secondary: var(--slate-500);
  --text-tertiary: var(--slate-400);
  --border: var(--slate-200);
  --border-light: var(--slate-100);

  --radius-sm: 6px;
  --radius-md: 10px;
  --radius-lg: 14px;

  --font: 'Outfit', system-ui, sans-serif;
  --transition: 180ms ease;
}

html {
  font-size: 16px;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

body {
  font-family: var(--font);
  color: var(--text-primary);
  background: var(--surface);
  line-height: 1.55;
  min-height: 100vh;
  display: flex;
  flex-direction: column;
}

a {
  color: var(--blue-600);
  text-decoration: none;
}
a:hover {
  text-decoration: underline;
}

/* ─── Header ─── */
.header {
  border-bottom: 1px solid var(--border);
  background: #fff;
}
.header-inner {
  max-width: 1120px;
  margin: 0 auto;
  padding: 14px 24px;
  display: flex;
  align-items: center;
  justify-content: space-between;
}
.logo {
  display: flex;
  align-items: center;
  gap: 10px;
  color: var(--blue-700);
  text-decoration: none;
}
.logo-icon {
  width: 28px;
  height: 28px;
}
.logo-text {
  font-weight: 700;
  font-size: 1.2rem;
  letter-spacing: -0.02em;
}
.header-tagline {
  font-size: 0.82rem;
  color: var(--text-tertiary);
  font-weight: 400;
  letter-spacing: 0.02em;
}

/* ─── Search Section ─── */
.search-section {
  background: linear-gradient(180deg, #fff 0%, var(--blue-50) 100%);
  padding: 56px 24px 64px;
  text-align: center;
}
.search-wrapper {
  max-width: 640px;
  margin: 0 auto;
}
.search-heading {
  font-size: clamp(1.6rem, 3.5vw, 2.1rem);
  font-weight: 700;
  letter-spacing: -0.03em;
  color: var(--slate-900);
  line-height: 1.2;
}
.search-sub {
  margin-top: 10px;
  color: var(--text-secondary);
  font-size: 0.95rem;
}
.search-form {
  margin-top: 28px;
}
.search-input-wrap {
  display: flex;
  align-items: center;
  background: #fff;
  border: 1.5px solid var(--border);
  border-radius: 25px;
  padding: 4px 4px 4px 16px;
  transition: border-color var(--transition), box-shadow var(--transition);
  gap: 8px;
  @supports (corner-shape: squircle) {
    corner-shape: squircle;
  }
}
.search-input-wrap:focus-within {
  border-color: var(--blue-500);
  box-shadow: 0 0 0 3px rgba(59, 114, 217, 0.12);
}
.search-icon {
  width: 20px;
  height: 20px;
  color: var(--text-tertiary);
  flex-shrink: 0;
}
.search-input {
  flex: 1;
  border: none;
  outline: none;
  font-family: var(--font);
  font-size: 1rem;
  color: var(--text-primary);
  background: transparent;
  padding: 10px 0;
}
.search-input::placeholder {
  color: var(--text-tertiary);
}
.search-btn {
  flex-shrink: 0;
  padding: 10px 24px;
  background: var(--blue-600);
  color: #fff;
  border: none;
  border-radius: 20px;
  font-family: var(--font);
  font-size: 0.9rem;
  font-weight: 600;
  cursor: pointer;
  transition: background var(--transition), transform 80ms ease;
  @supports (corner-shape: squircle) {
    corner-shape: squircle;
  }
}
.search-btn:hover {
  background: var(--blue-700);
}
.search-btn:active {
  transform: scale(0.97);
}
.search-btn:disabled {
  opacity: 0.5;
  cursor: not-allowed;
  transform: none;
}
.search-error {
  margin-top: 10px;
  font-size: 0.85rem;
  color: var(--red-600);
}

/* ─── Results Section ─── */
.results-section {
  flex: 1;
  padding: 0 24px 64px;
}
.results-inner {
  max-width: 1120px;
  margin: 0 auto;
}
.results-header {
  padding: 32px 0 20px;
}
.results-title {
  font-size: 1.1rem;
  font-weight: 500;
  color: var(--text-secondary);
}
.results-title span {
  font-weight: 700;
  color: var(--text-primary);
}

/* ─── Tabs ─── */
.tabs {
  display: flex;
  gap: 2px;
  border-bottom: 1.5px solid var(--border);
  overflow-x: auto;
  scrollbar-width: none;
}
.tabs::-webkit-scrollbar { display: none; }

.tab {
  display: flex;
  align-items: center;
  gap: 7px;
  padding: 12px 18px;
  background: none;
  border: none;
  font-family: var(--font);
  font-size: 0.88rem;
  font-weight: 500;
  color: var(--text-secondary);
  cursor: pointer;
  white-space: nowrap;
  position: relative;
  transition: color var(--transition);
}
.tab svg {
  width: 16px;
  height: 16px;
}
.tab::after {
  content: '';
  position: absolute;
  bottom: -1.5px;
  left: 0;
  right: 0;
  height: 2px;
  background: transparent;
  border-radius: 4px 4px 0 0;
  transition: background var(--transition);
  @supports (corner-shape: squircle) {
    corner-shape: squircle;
  }
}
.tab:hover {
  color: var(--text-primary);
}
.tab.active {
  color: var(--blue-600);
  font-weight: 600;
}
.tab.active::after {
  background: var(--blue-600);
}

/* ─── Tab Panels ─── */
.tab-panels {
  margin-top: 24px;
}
.tab-panel {
  display: none;
}
.tab-panel.active {
  display: block;
}

/* ─── Panel Toolbar (Filters) ─── */
.panel-toolbar {
  display: flex;
  align-items: flex-end;
  gap: 16px;
  padding: 16px 20px;
  background: var(--slate-50);
  border: 1px solid var(--border-light);
  border-radius: 20px;
  margin-bottom: 20px;
  flex-wrap: wrap;
}
.filter-group {
  display: flex;
  flex-direction: column;
  gap: 5px;
}
.filter-label {
  font-size: 0.75rem;
  font-weight: 600;
  color: var(--text-secondary);
  text-transform: uppercase;
  letter-spacing: 0.05em;
}
.filter-select,
.filter-date {
  font-family: var(--font);
  font-size: 0.85rem;
  padding: 7px 12px;
  border: 1px solid var(--border);
  border-radius: 12px;
  background: #fff;
  color: var(--text-primary);
  outline: none;
  transition: border-color var(--transition);
}
.filter-select:focus,
.filter-date:focus {
  border-color: var(--blue-500);
}
.filter-apply-btn {
  padding: 7px 18px;
  background: var(--slate-800);
  color: #fff;
  border: none;
  border-radius: 12px;
  font-family: var(--font);
  font-size: 0.82rem;
  font-weight: 600;
  cursor: pointer;
  transition: background var(--transition);
}
.filter-apply-btn:hover {
  background: var(--slate-900);
}

/* ─── Empty / Loading / Error States ─── */
.empty-state,
.error-state {
  padding: 48px 24px;
  text-align: center;
  color: var(--text-secondary);
  font-size: 0.95rem;
}
.error-state {
  color: var(--red-600);
  background: var(--red-50);
  border-radius: 20px;
  border: 1px solid var(--red-100);
}

.loader {
  display: flex;
  align-items: center;
  justify-content: center;
  padding: 48px 24px;
  gap: 6px;
}
.loader-dot {
  width: 8px;
  height: 8px;
  border-radius: 50%;
  background: var(--blue-500);
  animation: loader-pulse 1s ease-in-out infinite;
}
.loader-dot:nth-child(2) { animation-delay: 0.15s; }
.loader-dot:nth-child(3) { animation-delay: 0.3s; }

@keyframes loader-pulse {
  0%, 80%, 100% { opacity: 0.2; transform: scale(0.8); }
  40% { opacity: 1; transform: scale(1); }
}

/* ─── Drug Info Cards ─── */
.drug-info-grid {
  display: grid;
  gap: 16px;
}
.drug-card {
  border: 1px solid var(--border);
  border-radius: 20px;
  background: #fff;
  overflow: hidden;
}
.drug-card-header {
  padding: 20px 24px 16px;
  border-bottom: 1px solid var(--border-light);
}
.drug-card-brand {
  font-size: 1.15rem;
  font-weight: 700;
  color: var(--text-primary);
  letter-spacing: -0.01em;
}
.drug-card-generic {
  font-size: 0.85rem;
  color: var(--text-secondary);
  margin-top: 2px;
}
.drug-card-body {
  padding: 16px 24px 20px;
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
  gap: 16px;
}
.drug-detail {
  display: flex;
  flex-direction: column;
  gap: 3px;
}
.drug-detail-label {
  font-size: 0.72rem;
  font-weight: 600;
  text-transform: uppercase;
  letter-spacing: 0.06em;
  color: var(--text-tertiary);
}
.drug-detail-value {
  font-size: 0.9rem;
  color: var(--text-primary);
  line-height: 1.45;
}

/* ─── Adverse Events Table ─── */
.ae-table-wrap {
  overflow-x: auto;
  border: 1px solid var(--border);
  border-radius: 20px;
  background: #fff;
}
.ae-table {
  width: 100%;
  border-collapse: collapse;
  font-size: 0.85rem;
}
.ae-table th {
  text-align: left;
  padding: 12px 16px;
  font-weight: 600;
  font-size: 0.75rem;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  color: var(--text-secondary);
  background: var(--slate-50);
  border-bottom: 1px solid var(--border);
  white-space: nowrap;
  cursor: pointer;
  user-select: none;
}
.ae-table th:hover {
  color: var(--text-primary);
}
.ae-table th .sort-arrow {
  margin-left: 4px;
  opacity: 0.4;
}
.ae-table th.sorted .sort-arrow {
  opacity: 1;
  color: var(--blue-600);
}
.ae-table td {
  padding: 12px 16px;
  border-bottom: 1px solid var(--border-light);
  color: var(--text-primary);
  vertical-align: top;
}
.ae-table tr:last-child td {
  border-bottom: none;
}
.ae-table tr:hover td {
  background: var(--blue-50);
}

/* Badges */
.badge {
  display: inline-block;
  padding: 2px 9px;
  border-radius: 20px;
  font-size: 0.73rem;
  font-weight: 600;
  white-space: nowrap;
}
.badge-serious {
  background: var(--red-100);
  color: var(--red-700);
}
.badge-non-serious {
  background: var(--green-100);
  color: var(--green-600);
}
.badge-class-i {
  background: var(--red-100);
  color: var(--red-700);
}
.badge-class-ii {
  background: var(--amber-100);
  color: var(--amber-600);
}
.badge-class-iii {
  background: var(--green-100);
  color: var(--green-600);
}
.badge-ongoing {
  background: var(--amber-100);
  color: var(--amber-600);
}
.badge-completed {
  background: var(--green-100);
  color: var(--green-600);
}
.badge-terminated {
  background: var(--slate-100);
  color: var(--slate-600);
}

/* ─── Reactions list ─── */
.reactions-list {
  display: flex;
  flex-wrap: wrap;
  gap: 4px;
  margin-top: 4px;
}
.reaction-tag {
  font-size: 0.76rem;
  padding: 2px 8px;
  background: var(--blue-50);
  color: var(--blue-700);
  border-radius: 4px;
}

/* ─── Drug Labels (Accordion) ─── */
.label-card {
  border: 1px solid var(--border);
  border-radius: 20px;
  background: #fff;
  margin-bottom: 12px;
  overflow: hidden;
}
.label-card-header {
  padding: 18px 24px;
  border-bottom: 1px solid var(--border-light);
}
.label-card-name {
  font-size: 1.05rem;
  font-weight: 700;
}
.label-sections {
  padding: 8px 0;
}
.label-accordion {
  border-bottom: 1px solid var(--border-light);
}
.label-accordion:last-child {
  border-bottom: none;
}
.label-accordion-trigger {
  width: 100%;
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 14px 24px;
  background: none;
  border: none;
  font-family: var(--font);
  font-size: 0.88rem;
  font-weight: 600;
  color: var(--text-primary);
  cursor: pointer;
  text-align: left;
  transition: background var(--transition);
}
.label-accordion-trigger:hover {
  background: var(--slate-50);
}
.label-accordion-chevron {
  width: 16px;
  height: 16px;
  color: var(--text-tertiary);
  transition: transform var(--transition);
  flex-shrink: 0;
}
.label-accordion.open .label-accordion-chevron {
  transform: rotate(180deg);
}
.label-accordion-body {
  display: grid;
  grid-template-rows: 0fr;
  transition: grid-template-rows 250ms ease;
}
.label-accordion.open .label-accordion-body {
  grid-template-rows: 1fr;
}
.label-accordion-inner {
  overflow: hidden;
}
.label-accordion-text {
  padding: 0 24px 18px;
  font-size: 0.88rem;
  color: var(--slate-600);
  line-height: 1.65;
}

/* ─── Recall Cards ─── */
.recall-list {
  display: grid;
  gap: 12px;
}
.recall-card {
  border: 1px solid var(--border);
  border-radius: 20px;
  background: #fff;
  padding: 20px 24px;
}
.recall-card-top {
  display: flex;
  align-items: center;
  gap: 10px;
  margin-bottom: 10px;
  flex-wrap: wrap;
}
.recall-card-number {
  font-size: 0.82rem;
  font-weight: 600;
  color: var(--text-secondary);
}
.recall-card-reason {
  font-size: 0.92rem;
  color: var(--text-primary);
  line-height: 1.55;
  margin-bottom: 12px;
}
.recall-meta {
  display: flex;
  flex-wrap: wrap;
  gap: 20px;
  font-size: 0.8rem;
  color: var(--text-secondary);
}
.recall-meta-item strong {
  color: var(--text-primary);
  font-weight: 600;
}

/* ─── Top Reactions Summary ─── */
.ae-summary {
  margin-bottom: 20px;
  padding: 16px 20px;
  background: var(--blue-50);
  border: 1px solid var(--blue-100);
  border-radius: 20px;
}
.ae-summary-title {
  font-size: 0.8rem;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  color: var(--blue-700);
  margin-bottom: 10px;
}
.ae-bar-list {
  display: flex;
  flex-direction: column;
  gap: 6px;
}
.ae-bar-row {
  display: flex;
  align-items: center;
  gap: 10px;
  font-size: 0.82rem;
}
.ae-bar-label {
  width: 160px;
  flex-shrink: 0;
  color: var(--text-primary);
  font-weight: 500;
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}
.ae-bar-track {
  flex: 1;
  height: 8px;
  background: var(--blue-100);
  border-radius: 4px;
  overflow: hidden;
}
.ae-bar-fill {
  height: 100%;
  background: var(--blue-500);
  border-radius: 4px;
  transition: width 400ms ease;
}
.ae-bar-count {
  width: 48px;
  text-align: right;
  font-weight: 600;
  color: var(--text-secondary);
  font-size: 0.78rem;
}

/* ─── Pagination ─── */
.pagination {
  display: flex;
  align-items: center;
  justify-content: center;
  gap: 8px;
  margin-top: 24px;
}
.pagination-btn {
  padding: 7px 14px;
  border: 1px solid var(--border);
  border-radius: 12px;
  background: #fff;
  font-family: var(--font);
  font-size: 0.82rem;
  font-weight: 500;
  color: var(--text-primary);
  cursor: pointer;
  transition: background var(--transition), border-color var(--transition);
}
.pagination-btn:hover {
  background: var(--slate-50);
  border-color: var(--slate-300);
}
.pagination-btn:disabled {
  opacity: 0.4;
  cursor: not-allowed;
}
.pagination-info {
  font-size: 0.82rem;
  color: var(--text-secondary);
  padding: 0 8px;
}

/* ─── Footer ─── */
.footer {
  border-top: 1px solid var(--border);
  padding: 24px;
  text-align: center;
  font-size: 0.8rem;
  color: var(--text-secondary);
  margin-top: auto;
}
.footer-inner {
  max-width: 1120px;
  margin: 0 auto;
}
.footer-disclaimer {
  margin-top: 6px;
  font-size: 0.75rem;
  color: var(--text-tertiary);
}

/* ─── Responsive ─── */
@media (max-width: 768px) {
  .header-tagline {
    display: none;
  }
  .search-section {
    padding: 36px 16px 44px;
  }
  .results-section {
    padding: 0 16px 48px;
  }
  .tab {
    padding: 10px 14px;
    font-size: 0.82rem;
  }
  .panel-toolbar {
    flex-direction: column;
    align-items: stretch;
    gap: 12px;
  }
  .drug-card-body {
    grid-template-columns: 1fr;
  }
  .ae-bar-label {
    width: 100px;
  }
}

@media (max-width: 480px) {
  .tab svg {
    display: none;
  }
  .search-input-wrap {
    flex-wrap: wrap;
  }
  .search-btn {
    width: 100%;
  }
}